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目的分析成都市龙泉驿区产前筛查数据,评价产前筛查技术对该区出生缺陷的预防作用。方法对2010年11月-2012年12月在成都市龙泉驿区产前筛查中心进行中孕期产前筛查的10 230例孕妇血清样本进行检验分析,从而得出孕妇罹患21-三体综合征、18-三体综合征和开放性神经管缺陷的风险率,借助高风险转诊、孕期追踪及妊娠结局随访等方式对产前筛查结果进行核实及评价。结果成都市龙泉驿区10 230例产前筛查数据中21-三体综合征、18-三体综合征及开放性神经管缺陷筛查高风险率分别为6.02%、0.42%及0.57%,高风险孕妇产前诊断依从率为51.56%,其中57例开放性神经管缺陷筛查高风险的孕妇中有53例进行了系统超声诊断(依从率为92.98%),而647例21-三体或18-三体综合征高风险孕妇仅47.30%进行了羊水穿刺,超声诊断与羊水穿刺产前诊断依从率差异有统计学意义(P<0.05),通过诊断确诊3例21-三体综合征患者。结论中孕期产前筛查对控制成都市龙泉驿区出生缺陷具有重要作用,该区产前筛查21-三体或18-三体综合征高风险孕妇产前诊断依从率有待提高。
Objective To analyze prenatal screening data in Longquanyi District of Chengdu and evaluate the preventive effect of prenatal screening on birth defects in this area. Methods A total of 10 230 pregnant women with prenatal screening during prenatal screening at the Longquanyi Prenatal Screening Center in Chengdu from November 2010 to December 2012 were tested and analyzed to find out that the pregnant women had 21-trisomy syndrome , 18-trisomy syndrome and the risk of open neural tube defects. The prenatal screening results were verified and evaluated with high-risk referral, follow-up of pregnancy and follow-up of pregnancy outcomes. Results The high risk rates of screening 21-trisomy, 18-trisomy and open neural tube defects in 10 230 prenatal screening data in Longquanyi District of Chengdu were 6.02%, 0.42% and 0.57%, respectively The prenatal diagnostic compliance rate of pregnant women with risk was 51.56%. Among them, 53 of 57 pregnant women with high risk of open neural tube defects were diagnosed by systematic ultrasound (compliance rate was 92.98%), while 647 cases of 21-trisomy or The amniocentesis was performed in only 47.30% of pregnant women with high risk of trisomy. The prenatal diagnostic compliance rate was significantly different between ultrasound diagnosis and amniocentesis (P <0.05). Diagnosis of three cases of trisomy 21 . Conclusion Prenatal screening during the first trimester plays an important role in controlling birth defects in Longquanyi District of Chengdu. Prenatal screening of prenatal screening for high risk pregnant women with 21-trisomy or 18-trisomy syndrome needs to be improved.