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目的：观察刺五加皂苷单体Ｓｃ３（ＡｃａｎｔｈｏｐａｎａｘＳｅｎｔｉｃｏｓｉｄｅＣ３）对培养的Ｗｉｓｔａｒ大鼠乳鼠心肌细胞自发性搏动及动作电位电参数的影响。方法：将５０～８００μｇ／ｍｌＳｃ３，分别加入到培养４～６ｄ后的Ｗｉｓｔａｒ大鼠乳鼠心肌细胞的培养液中，依次记录加药前、后自发性搏动及动作电位电参数的变化。结果：Ｓｃ３可剂量依赖性地抑制被培养的Ｗｉｓｔａｒ大鼠乳鼠心肌细胞的自发性搏动及动作电位的电参数，其作用与０．４μｇ／ｍｌ尼莫地平相似，而该作用被８０μｇ／ｍｌＣａ２＋所反转。结论：Ｓｃ３能够阻滞Ｃａ２＋通道
Objective: To observe the effects of acanthopanax senticoside C3 on spontaneous beating and action potential parameters of cultured neonatal rat cardiomyocytes. Methods: The ScV of 50 ~ 800μg / ml was added into the culture medium of Wistar rat neonatal rat cardiocytes cultured for 4 ~ 6 days. The changes of spontaneous beats and the action parameters were recorded before and after dosing. Results: Sc3 could inhibit the spontaneous beating and action potential parameters of cultured cardiomyocytes of Wistar rats in a dose-dependent manner. The effect of Sc3 was similar to that of nimodipine 0.4μg / ml, which was inhibited by 80μg / ml Ca2 + Reversed. Conclusion: Sc3 blocks Ca2 + channels