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糖皮质激素类药物用于治疗类风湿性关节炎一直存在争议。早期临床研究发现,糖皮质激素类药物可能对患者的疼痛具有很好地抑制作用,因此可被大量应用于治疗类风湿性关节炎,对改善临床症状产生积极的作用。但随着使用剂量和时间的增加,其产生的不良反应也随之增多,给患者带来了危害,因此如何合理使用糖皮质激素类药物是治疗类风湿性关节炎的关键所在。本文将从类风湿性关节炎的发病机制,糖皮质激素类药物的作用机制和特点,及其靶向制剂的研究等方面进行综述。
Glucocorticoid drugs for the treatment of rheumatoid arthritis has been controversial. Early clinical studies found that glucocorticoid drugs may have a good inhibitory effect on the patient’s pain, and therefore can be widely used in the treatment of rheumatoid arthritis, to improve the clinical symptoms have a positive effect. However, with the increase of dose and time, the adverse reactions are also increased, which brings harm to patients. Therefore, how to use glucocorticoids reasonably is the key to the treatment of rheumatoid arthritis. This article reviews the pathogenesis of rheumatoid arthritis, the mechanism and characteristics of glucocorticoid drugs and the research of its targeted agents.