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目的评价补肾方联合雄激素及免疫抑制剂治疗慢性再生障碍性贫血(CAA)的临床疗效,以确立中西医结合治疗CAA的优化治疗方案。方法将39例CAA患者随机分为3组,对照组(16例)采用司坦唑醇片联合环孢素A(CsA),试验一组(11例)辨证采用补肾Ⅰ、Ⅱ、Ⅲ号方治疗,试验二组(12例)在对照组基础上加用补肾Ⅰ、Ⅱ、Ⅲ号方治疗,疗程6个月。分别观察各组临床疗效及治疗前后患者外周血清促红细胞生成素(EPO)、干扰素-γ(IFN-γ)水平的变化情况。结果 3组在临床疗效、外周血象改善方面差异无统计学意义(P>0.05),但试验二组在贫血症状及中医证候的改善方面明显优于另外2组(P<0.05),并能显著降低IFN-γ水平(P<0.05)。结论补肾方联合雄激素及免疫抑制剂治疗CAA在临床疗效、改善症状及提高血常规计数方面均优于单用中药或单用西药治疗。
Objective To evaluate the clinical efficacy of Bushen Fang combined with androgen and immunosuppressive agents in the treatment of chronic aplastic anemia (CAA) in order to establish the optimized treatment of CAA combined with traditional Chinese and Western medicine. Methods Thirty-nine patients with CAA were randomly divided into three groups. The control group (16 cases) received stanozolol and cyclosporin A (CsA). One group (11 cases) The treatment and trial groups (12 cases) were treated with Bushen Ⅰ, Ⅱ and Ⅲ on the basis of the control group for 6 months. The changes of peripheral blood serum erythropoietin (EPO) and interferon-γ (IFN-γ) levels in each group were observed before and after treatment. Results There was no significant difference between the three groups in the clinical efficacy and the improvement of peripheral blood (P> 0.05). However, the second group was significantly better than the other two groups in improving anemia symptoms and TCM syndromes (P <0.05) Significantly reduced the level of IFN-γ (P <0.05). Conclusion Bushenfang combined with androgen and immunosuppressive agents in the treatment of CAA in clinical efficacy, improve symptoms and improve blood count are better than single medicine or Western medicine alone.