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测定肠溶包衣片性能的根据是一种经改良的崩解试验。但符合USPXY版规定的试验的阿司匹林肠溶片,有的在人工胃液中仍会释放。另外,有的阿司匹林肠溶片生物利用度不够满意。包衣的另一优点是控制空气中水蒸汽进入而增加药物的稳定性。本文评价了酞酸醋酸纤维素(CAP)和聚醋酸酞酸乙烯酯(PVAP)的肠溶特性。还研究了两种添加剂[增塑剂酞酸二乙酯、色素红色氧化铁(99.4～99.7％Fe_2O_3)]对这些特性的影响。CAP包衣处方的溶剂是二氯甲烷-甲醇的共沸混合物(含93％二氯甲烷),PVAP的溶剂是50:50(重量比)的二氯甲烷-
The basis for determining the properties of enteric-coated tablets is an improved disintegration test. But in line with the USPXY version of the test aspirin enteric-coated tablets, and some will still be released in the artificial gastric juice. In addition, some aspirin enteric-coated tablets bioavailability is not satisfactory. Another advantage of the coating is to control the water vapor in the air to increase the stability of the drug. This article evaluated the enteric properties of cellulose acetate phthalate (CAP) and polyvinyl acetate phthalate (PVAP). The effects of two additives [plasticizer diethyl phthalate, pigment red iron oxide (99.4-99.7% Fe_2O_3]] on these properties were also studied. The solvent for the CAP coating formulation was a dichloromethane-methanol azeotrope (containing 93% methylene chloride) and the solvent for PVAP was a 50:50 (weight ratio) solution of methylene chloride-