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目的探讨小剂量红霉素治疗早产儿喂养不耐受的疗效。方法72例喂养不耐受早产儿随机分为2组:对照组30例,给予常规处理;治疗组42例,在常规治疗基础上加小剂量红霉素静脉注射3～5 mg.kg-1.d-1,1次/d,用药至能耐受肠道喂养3 d后。结果治疗组与对照组比较:呕吐持续时间分别为(3.28±2.30)、(4.86±2.60)d(P<0.05);腹胀持续时间分别为(3.60±2.26)、(4.97±2.48)d(P<0.05);达全肠道营养时间分别为(13.20±4.36)、(16.15±4.08)d(P<0.05);恢复出生体重时间分别为(10.37±2.34)、(14.58±2.23)d(P<0.05)。2组日均大便次数无明显差异,均未见肝功能损害以及其他药物不良反应。结论小剂量红霉素治疗对早产儿喂养不耐受有效,未见明显不良反应。
Objective To investigate the efficacy of low-dose erythromycin in treating intolerance in preterm infants. Methods 72 preterm infants with intolerance were randomly divided into 2 groups: control group, 30 cases, given conventional treatment; treatment group, 42 cases, on the basis of conventional treatment, plus a small dose of erythromycin intravenous injection of 3 ~ 5 mg.kg-1 .d-1,1 times / d, medication to be able to tolerate intestinal feeding after 3 d. Results The duration of vomiting was (3.28 ± 2.30) days and (4.86 ± 2.60 days) respectively in the treatment group and the control group (P <0.05). The duration of abdominal distension was (3.60 ± 2.26) and (4.97 ± 2.48) d (P <0.05). The time to reach total intestine nutrition was (13.20 ± 4.36) days and (16.15 ± 4.08) days respectively, and the time of birth weight recovery were (10.37 ± 2.34), (14.58 ± 2.23) days <0.05). There was no significant difference in average daily stool frequency between the two groups. No adverse effects of liver function and other drugs were observed. Conclusion Low-dose erythromycin treatment is ineffective in feeding infants with preterm infants, and no obvious adverse reactions are observed.