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目的研究女性月经失调与亚临床甲状腺功能减退症(SCH)的关系。方法用化学发光法检测322例不明原因月经失调患者(实验组)的甲状腺激素水平,结果按临床症状和年龄分为月经过多组、月经量少组、闭经组、月经不规律组4组及<40岁组、≥40岁组2个年龄组,并收集240例健康女性为对照组。比较实验组和对照组的SCH发病率、TSH>95%CI上限比率的差异,并评估SCH发病风险。结果月经过多组、月经量少组相比对照组SCH发病率差异具有统计学意义,(χ~2值分别为19.46、7.71,P<0.01);月经过多组、月经量少组相比对照组的SCH发病风险较高(OR_(月经过多组)=10.261,P<0.01;OR_(月经量少组)=5.566,P<0.05);≥40岁组的SCH发病风险高于<40岁组(OR=3.479,P<0.01)。结论 SCH可导致女性月经过多或月经量少,尤其是年龄40岁以上患者。
Objective To investigate the relationship between female menstrual disorders and subclinical hypothyroidism (SCH). Methods Thyroid hormone levels in 322 patients with unexplained menstrual disorders (experimental group) were detected by chemiluminescence. The results were divided into four groups according to clinical symptoms and age, including menorrhagia group, menorrhagia group, amenorrhea group, irregular menstruation group and <40 years old group,> 40 years old group two age groups, and collected 240 healthy women as the control group. The incidence of SCH and the ratio of upper limit of TSH> 95% CI in experimental group and control group were compared and the risk of SCH was assessed. Results There were significant differences in the incidence of schizophrenia between the menorrhagia group and the menorrhagia group compared with the control group (χ ~ 2 = 19.46, 7.71, P <0.01). Compared with the menorrhagia group and the menstruation group The risk of SCH was higher in the control group (OR_ (menorrhagia) = 10.261, P <0.01; OR_ (menses less) = 5.566, P <0.05) The age group (OR = 3.479, P <0.01). Conclusion SCH can lead to menorrhagia or menstrual flow less, especially in patients over the age of 40 years.