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目的观察西咪替丁防治脑出血后应激性上消化道出血的临床作用。方法将92例脑出血合并上消化道出血患者按随机法分为对照组和观察组,各46例,两组均给予常规治疗,观察组在常规治疗同时给予西咪替丁注射治疗;观察比较两组患者胃液PH变化,大便潜血试验平均转阴时间及转阴率,并比较两组患者临床疗效。结果治疗后,观察组较对照组胃液PH显著升高,差异有统计学意义(P<0.05);大便潜血试验显示,观察组患者较对照组平均转阴时间明显缩短,且转阴率明显升高,差异均有统计学意义;观察组临床有效率(80.43%)显著高于对照组(58.70%),差异有统计学意义。结论西咪替丁防治脑出血后应激性上消化道出血,可升高胃液酸碱度,缩短转阴时间,促进胃黏膜修复,值得临床推崇。
Objective To observe the clinical effect of cimetidine in preventing and treating upper gastrointestinal bleeding after intracerebral hemorrhage. Methods Ninety-two patients with cerebral hemorrhage complicated with upper gastrointestinal bleeding were randomly divided into control group and observation group, with 46 cases in each group. Both groups were given conventional treatment. The observation group was treated with cimetidine injection routinely. The observation and comparison Two groups of patients with gastric juice PH changes, fecal occult blood test average time and negative conversion rate, and compared the clinical efficacy of two groups of patients. Results After treatment, the gastric juice PH in the observation group was significantly higher than that in the control group (P <0.05). The fecal occult blood test showed that the mean negative conversion time of the observation group was significantly shorter than that of the control group, and the negative conversion rate was significantly increased The differences were statistically significant. The clinical effective rate (80.43%) in the observation group was significantly higher than that in the control group (58.70%), the difference was statistically significant. Conclusion Cimetidine prevents and treats upper gastrointestinal bleeding after intracerebral hemorrhage, which can increase the pH value of gastric juice, shorten the time of negative conversion and promote the repair of gastric mucosa. It is worth to be respected clinically.