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目的观察急性心肌梗死(AMI)患者早期溶栓治疗效果及相关因素。方法对2002年6月至2005年5月住院治疗的AMI患者152例按发病到溶栓开始时间计算,分成<2h,2~4h,4~6h三个组,观察溶栓后血管再通率、心律、血压变化及4周EF值等。结果<2h、2~4h、4~6h三组溶栓再通率分别为87.10%、76.92%、64.00%,2h内溶栓再通率明显高于4~6h。组间差异均具有显著性意义,第4周LVEF值比较再通组与未通组心功能差异具有显著性意义。结论AMI患者开展绿色通道早期急诊溶栓为AMI病人赢得治疗时间,尽早使梗死部位相关血管(IRA)再通,尽早使心肌得到再灌注是缩小梗死面积,降低死亡率,改善AMI预后的关键。溶栓距发病时间愈短,血管再通率愈高。
Objective To observe the effect and related factors of early thrombolytic therapy in patients with acute myocardial infarction (AMI). Methods From June 2002 to May 2005, 152 patients with AMI who were hospitalized were divided into two groups according to their onset of onset of thrombolysis and were divided into three groups: <2h, 2h, 4h, 4h and 6h. The rate of recanalization after thrombolysis , Heart rate, blood pressure changes and 4 weeks EF value. Results The recanalization rates of thrombolysis in 2h, 2 ~ 4h and 4 ~ 6h groups were 87.10%, 76.92% and 64.00%, respectively. The rate of thrombolysis recanalization within 2h, 2h and 4h was significantly higher than that of 4h to 6h. There was significant difference between the two groups. There was significant difference between the LVEF values in the 4th week and those in the recanalization group and the failed group. Conclusions Early acute thrombolytic therapy of green channel in patients with acute myocardial infarction (AMI) can shorten the infarct size, reduce the mortality and improve the prognosis of AMI. The shorter the time from thrombolysis, the higher the rate of vascular recanalization.