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目的:通过检测新辅助化疗前后乳腺癌CXCR4的表达水平,了解新辅助化疗对CXCR4表达的影响。方法:我院2011~2012年行新辅助化疗的80例乳腺癌患者化疗前肿瘤原发灶空心针穿刺活检及术后病理石蜡标本,利用En Vision免疫组化法检测乳腺癌组织中CXCR4的表达水平,比较新辅助化疗前后CXCR4水平的变化。结果:68例CXCR4表达水平减弱,12例表达水平无改变,新辅助化疗后的CXCR4表达水平较化疗前明显减弱(P<0.01)。结论:新辅助化疗可显著降低乳腺癌CXCR4的表达水平。
OBJECTIVE: To investigate the effect of neoadjuvant chemotherapy on CXCR4 expression by detecting the expression of CXCR4 in breast cancer before and after neoadjuvant chemotherapy. Methods: 80 cases of breast cancer patients undergoing neoadjuvant chemotherapy from 2011 to 2012 were treated with the hollow needle aspiration biopsy and postoperative pathological paraffin specimens before chemotherapy. Envision immunohistochemistry was used to detect the expression of CXCR4 in breast cancer tissues Level before and after neoadjuvant chemotherapy CXCR4 levels. Results: The expression of CXCR4 was decreased in 68 cases and the expression of CXCR4 in 12 cases was not changed. The expression of CXCR4 in neoadjuvant chemotherapy group was significantly lower than that before chemotherapy (P <0.01). Conclusion: Neoadjuvant chemotherapy can significantly reduce the expression of CXCR4 in breast cancer.