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用131I标记抗癌胚抗原单克隆抗体(CEAMcAb)对临床难于诊断和处理的大肠癌腹内复发病变行放射免疫显像(RII).11例患者中10例为阳性,RII共检出≥2cm的癌症灶17/18处,假阳性、假阴性各1处.故其对≥2cm癌症灶的探测灵敏度和阳性图像的实际符合率均为94.4%.RII对血CEA阴性、隐匿性复发和腹内广泛播散者均有较高的诊断价值.RII还能判断复发癌是否侵犯膀胱.
131I-labeled anti-carcinoembryonic antigen monoclonal antibody (CEAMcAb) was used to perform radioimmunoimaging (RII) on the intra-abdominal recurrent lesions of colorectal cancer that are difficult to diagnose and treat. Ten of the 11 patients were positive, and RII detected a total of 17/18 cancer foci ≥2cm, with 1 false positive and 1 false negative. Therefore, the detection accuracy of the ≥2cm cancer foci and the actual coincidence rate of positive images were both 94.4%. RII is of high diagnostic value for blood CEA negative, occult recurrence, and widespread intra-abdominal dissemination. RII can also determine whether recurrent cancer invades the bladder.