论文部分内容阅读
目的探讨中期因子MK和CD105在下咽鳞状细胞癌组织中的表达及临床意义。方法采用免疫组织化学方法检测47例下咽鳞状细胞癌组织中MK的表达和CD105标记的微血管密度MVD情况,并根据检测结果分析与下咽癌各临床病理因素之间的关系。结果 MK的阳性表达率为68.08%,MK表达为阳性时CD105标记的MVD值(37.21±7.94)明显高于MK表达为阴性时的MVD值(25.11±7.94)(P<0.01),二者表达与临床分期、淋巴结转移有关。结论 MK及CD105标记的微血管密度(MVD)与下咽癌分期及淋巴结转移具有相关性,与下咽癌的分化程度无相关性,可作为一组有价值的肿瘤标记和预后指标。
Objective To investigate the expression and clinical significance of midkine (MK) and CD105 in squamous cell carcinoma of the hypopharynx. Methods Immunohistochemistry was used to detect the expression of MK and CD105-labeled MVD in 47 squamous cell carcinoma of the hypopharynx. The relationship between MVD and clinicopathological parameters of hypopharyngeal carcinoma was analyzed. Results The positive expression rate of MK was 68.08%. The MVD value of CD105 marked by MK expression was significantly higher than that of MK negative expression (37.21 ± 7.94 vs 25.11 ± 7.94, P <0.01) And clinical stage, lymph node metastasis. Conclusion MVD associated with MK and CD105 is correlated with staging and lymph node metastasis of hypopharyngeal carcinoma and has no correlation with the degree of differentiation of hypopharyngeal carcinoma. It may serve as a valuable indicator of tumor marker and prognosis.