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目的:探讨多普勒超声监测对新生儿缺氧缺血性脑病(HIE)的早期诊断价值。方法:选取2010年5月～2012年10月在我院分娩的缺氧缺血性脑病新生儿42例设为实验组,同期在我院分娩的健康新生儿42例设为对照组,两组新生儿在24h、48h、72h采取多普勒超声监测,观察患儿脑内收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)和阻力指数(RI)的变化。结果:出生后患儿的PSV和EDV逐渐增高,而RI有逐渐降低的趋势。24h时,轻度窒息和中重度窒息患儿的PSV、EDV、RI和对照组比较,P<0.05差异具有统计学意义;48h时,中重度窒息患儿的PSV、EDV、RI和对照组比较,P<0.05差异具有统计学意义;轻度窒息患儿的PSV、EDV、RI和对照组比较,P>0.05差异不具有统计学意义;72h时,轻度窒息和中重度窒息患儿的PSV、EDV、RI和对照组比较,P>0.05差异不具有统计学意义。结论:多普勒超声监测对新生儿缺氧缺血性脑病的早期诊断具有很高的价值,操作方便,实用性强,可用于该类疾病的早期诊断。
Objective: To investigate the value of Doppler ultrasound in the early diagnosis of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Forty-two neonates with hypoxic-ischemic encephalopathy who delivered in our hospital from May 2010 to October 2012 were selected as the experimental group and 42 healthy newborns delivered in our hospital during the same period as the control group. Two groups The newborns were monitored by Doppler ultrasound at 24h, 48h, 72h to observe the change of peak cerebral blood flow velocity (PSV), end diastolic velocity (EDV) and resistance index (RI). Results: After birth, PSV and EDV gradually increased, while RI tended to decrease gradually. At 24 hours, PSV, EDV, RI in mild asphyxia and mild to moderate asphyxia were significantly higher than those in control group (P <0.05). There was significant difference between PSV, EDV, RI and control group , P <0.05 was statistically significant; PSV, EDV, RI in children with mild asphyxia compared with the control group, P> 0.05 difference was not statistically significant; 72h, mild asphyxia and moderate to severe asphyxia in children with PSV , EDV, RI and control group, P> 0.05 difference was not statistically significant. Conclusion: Doppler ultrasound monitoring is of great value in the early diagnosis of neonatal hypoxic-ischemic encephalopathy. It is easy to operate and practical and can be used for the early diagnosis of such diseases.