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目的 探讨中药呆聪液对老龄鼠痴呆模型免疫功能的影响。方法 选择 2 2月龄的老龄大鼠 ,用双侧电解损毁脑基底核法 ,造成学习和记忆功能障碍的痴呆动物模型 ,用 3H- Td R掺入 DNA法试验了呆聪液对淋巴细胞增殖的影响 ,用脾细胞介导红细胞溶血的紫外分光光度计测定法测定脾细胞抗体产生能力。结果 呆聪液明显提高痴呆动物的淋巴细胞增殖能力 ,与模型组比较 ( P<0 .0 1 )差异显著 ,还明显提高脾细胞抗体产生能力 ,与模型组比较 ( P<0 .0 1 )差异显著。结论 呆聪液显著提高痴呆动物模型的细胞免疫功能和体液免疫功能 ,其效果优于脑复康组。
Objective To investigate the effects of traditional Chinese medicine Pucon Liquid on the immune function of senile dementia model. Methods Aged 22-month-old rats were randomly divided into three groups: aged rats (22-month-old), dementia model with learning and memory dysfunction caused by bilateral electrolytic destruction of brain basal ganglia, and 3H-TdR- The spleen cell-mediated erythrocyte hemolysis was measured by UV spectrophotometry for the determination of antibody production by splenocytes. Results Compared with the model group (P <0.01), Daicong solution significantly improved the ability of lymphocyte proliferation of dementia animals, and significantly enhanced the antibody production ability of spleen cells compared with the model group (P <0.01) Significant difference. Conclusions Daicong solution can significantly improve the cellular immune function and humoral immune function in animal model of dementia, which is superior to Naofukang.