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为寻找新型活性杂环化合物,通过活性亚结构拼接,以取代苯酚和氯乙酸为起始原料,经醚化、缩合、烃基化和氨解反应,设计并采用微波辅助合成了6种未见文献报道的含苯并咪唑环的1,3,4-噻二唑酰胺衍生物,其结构经红外和核磁共振氢谱确证。初步抑菌活性测试结果表明,所有目标化合物对5种供试病原菌都表现出一定的抑菌活性,其中,化合物7c、7d、7e和7f在50 mg/L下对5种供试病原菌的抑制率均达到80%以上。
In order to find a new type of active heterocyclic compounds, six new kinds of heterocyclic compounds have been synthesized via active substructure splicing, using phenol and chloroacetic acid as starting materials, etherification, condensation, alkylation and ammonolysis. The reported benzimidazole ring 1,3,4- thiadiazole amide derivatives, the structure confirmed by IR and 1H nuclear magnetic resonance. The results of preliminary antibacterial activity test showed that all of the target compounds showed certain antibacterial activities against the five tested pathogens. Among them, the inhibition of five tested pathogens by compounds 7c, 7d, 7e and 7f at 50 mg / L Rate reached more than 80%.