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作者给24505例手术病人,静脉、直肠内应用灭滴灵(metronidazle)。其中有菌手术组6303人,无菌手术组18202人。直肠内每次给药500毫克,8小时一次,药物吸收率为78.3%,血液内有效药物浓度稳定维持。结果有菌手术组,直肠、静脉用药等效,伤口感染率和厌氧菌感染率显著下降。无菌手术组静脉用药伤口感染率下降,对厌氧菌感染无影响。直肠用药伤口感染无影响,而对厌氧菌感染率下降。作者复习文献,认为上述结果说明直肠用药,对于
The authors applied metronidazle to 24,505 surgical patients, intravenously and rectally. Among them, there were 6303 patients in the bacterial surgery group and 18,202 in the aseptic surgery group. Rectally administered 500 mg each time, 8 hours once, the drug absorption rate was 78.3%, the blood concentration of effective drug maintenance. The results of a bacterial surgery group, rectal, intravenous drug equivalent, wound infection rate and anaerobic infections decreased significantly. Aseptic surgery group intravenous wound infection rate decreased, no effect on anaerobic infections. Rectal wound infection has no effect, while the decline in the rate of anaerobic infections. The authors review the literature, believing that the above results illustrate rectal administration