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肾移植是治疗终末期肾病的最佳手段,但移植过程中会发生热缺血、冷缺血及缺血再灌注等损伤,影响移植肾近、长期预后。大量研究表明移植肾损伤与线粒体自噬介导的细胞凋亡有密不可分的联系,ALDH2在其中可能扮演着重要的角色。ALDH2可以双向调控线粒体自噬,影响细胞凋亡的进程,减少或增加移植肾损伤。本文综述了ALDH2调控线粒体自噬与移植肾损伤之间的关系,为肾移植领域提出可能的新靶点和研究方向。
Kidney transplantation is the best treatment of end-stage renal disease, but the process of transplantation will occur hot ischemia, cold ischemia and ischemia-reperfusion injury, affecting the short-term, long-term prognosis of transplanted kidney. Numerous studies have shown that there is a close relationship between renal allograft injury and mitochondrial autophagy-mediated apoptosis. ALDH2 may play an important role in this process. ALDH2 can regulate mitochondrial autophagy bidirectionally, affect the process of apoptosis and reduce or increase the renal graft injury. This review summarizes the relationship between ALDH2 regulation of mitochondrial autophagy and renal allograft injury, and proposes possible new targets and research directions for renal transplantation.