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目的探讨院前无创机械通气辅助药物治疗急性心肌梗死并左心衰竭的临床效果。方法将急性心肌梗死并左心衰竭患者208例随机分为试验组和对照组各104例。2组患者均给予重组人B型脑钠肽联合替罗非班治疗,试验组给予院前无创机械通气治疗,对照组给予院前常规治疗。观察2组左心室功能、临床疗效及并发症发生情况。结果治疗后2组患者左心室射血分数显著升高,而左心室收缩末期内径和左心室舒张末期内径水平均降低,且试验组变化幅度明显大于对照组;治疗后总有效率为91.35%高于对照组的76.92%,并发症发生率为7.69%明显低于对照组的25.00%,差异均有统计学意义(P<0.05)。结论院前无创机械通气辅助重组人B型脑钠肽联合替罗非班治疗急性心肌梗死并左心衰竭可显著改善患者左心功能,优于常规治疗。
Objective To investigate the clinical effect of prehospital non-invasive mechanical ventilation in the treatment of acute myocardial infarction and left heart failure. Methods 208 patients with acute myocardial infarction and left heart failure were randomly divided into experimental group and control group of 104 cases. Two groups of patients were given recombinant human B-type natriuretic peptide combined with tirofiban treatment, the experimental group was given preoperative non-invasive mechanical ventilation, while the control group was given pre-hospital routine treatment. Left ventricular function, clinical efficacy and complications were observed in two groups. Results After treatment, left ventricular ejection fraction was significantly increased in both groups, while the left ventricular end-systolic diameter and left ventricular end-diastolic diameter decreased, and the changes in the experimental group were significantly greater than those in the control group. The total effective rate was 91.35% 76.92% in the control group, the incidence of complications was 7.69%, which was significantly lower than that of the control group (25.00%), the differences were statistically significant (P <0.05). Conclusion Prehospital non-invasive mechanical ventilation-assisted recombinant human B-type natriuretic peptide combined with tirofiban in the treatment of acute myocardial infarction and left ventricular failure can significantly improve left ventricular function in patients, superior to conventional treatment.