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目的研究兰索拉唑联合康复新治疗消化性溃疡的临床疗效及复发率。方法确诊为消化性溃疡109例,分为观察组55例,予兰索拉唑20mg/次,2次/d,康复新10ml/次,3次/d,对照组单用兰索拉唑,均4周。观察治疗过程中症状改善情况及幽门螺菌根治率。随访复发率。结果治疗组治愈率72.7%,总有效率92.7%,对照组治愈率53.7%,总有效率72.7%,两组治愈率、总有效率分别比较,差异均有统计学意义(均P<0.01)。幽门螺菌根治率治疗组为90.9%,对照组为74.1%,两者比较,差异有统计学意义(P<0.01)。一年后,治疗组复发率为14.5%,对照组复发率为24.1%,复发率比较,差异有统计学意义(P<0.01)。两组治疗前后,血粪尿常规及肝肾功能检查均无异常。结论兰索拉唑联合康复新治疗消化性溃疡的临床疗效佳,复发率低,不良反应少。
Objective To study the clinical efficacy and relapse rate of lansoprazole combined with rehabilitation in the treatment of peptic ulcer. Methods One hundred and ten patients with peptic ulcer were diagnosed as peptic ulcer with 55 cases in the observation group, 20 mg lansoprazole, 2 times / d, 10 ml / All 4 weeks. Observe the improvement of symptoms during treatment and the cure rate of Helicobacter pylori. Follow-up rate of recurrence. Results The cure rate of the treatment group was 72.7%, the total effective rate was 92.7%, the cure rate of the control group was 53.7%, the total effective rate was 72.7%. The cure rate and total effective rate of the two groups were statistically significant (all P <0.01) . The cure rate of Helicobacter pylori was 90.9% in the treatment group and 74.1% in the control group, the difference was statistically significant (P <0.01). One year later, the recurrence rate was 14.5% in the treatment group and 24.1% in the control group. The recurrence rate was statistically significant (P <0.01). Before and after treatment, blood excretion and urine routine and liver and kidney function tests were normal. Conclusions Lansoprazole combined with rehabilitation new treatment of peptic ulcer clinical efficacy, low recurrence rate, fewer adverse reactions.