论文部分内容阅读
目的:本研究检测后循环缺血性脑卒中(posterior circulation ischemic stroke,PCIS)患者脑脊液tau、S100B、神经烯醇化酶(neuron-specific Enolase;NSE)浓度,以及调查这些生化标志物与初始卒中严重程度、长期的功能预后之间的关系。方法:23例PCIS患者的脑脊液tau、S100B、NSE浓度进行检测,我们评估脑脊液生化标志物浓度与卒中发作24小时NIHSS评分以及卒中后3个月的mRS评分之间关系。结果:“轻度卒中组”(NIHSS≤7)脑脊液tau、S100B浓度显著低于“中重度卒中组”(NIHSS>7)(P<0.05)。两组脑脊液NSE浓度差异无统计学意义(P>0.05)。“好的功能预后组”(mRS1-3)脑脊液tau、S100B浓度显著低于“差的功能预后组”(mRS4-6)(P<0.05),而两组脑脊液NSE浓度差异也无统计学意义(P>0.05)。结论 :PCIS患者脑脊液tau、S100B浓度与卒中特征有关,而NSE的脑脊液浓度,与卒中特征无关。
Aims: We examined the levels of tau, S100B and neuron-specific enolase (NSE) in cerebrospinal fluid in patients with posterior circulation ischemic stroke (PCIS) and investigated the relationship between these biochemical markers and the severity of initial stroke Degree, long-term relationship between functional prognosis. METHODS: Cerebrospinal fluid concentrations of tau, S100B and NSE were measured in 23 PCIS patients. We assessed the relationship between cerebrospinal fluid biomarkers concentration and the NIHSS score at 24 hours after stroke and the mRS score at 3 months after stroke. Results: The levels of tau and S100B in cerebrospinal fluid in patients with mild stroke group (NIHSS ≤ 7) were significantly lower than those in patients with moderate to severe stroke group (NIHSS> 7) (P <0.05). There was no significant difference in NSE concentration between the two groups (P> 0.05). Cerebral spinal fluid tau and S100B levels were significantly lower in the “good functional prognosis group” (mRS1-3) than those in the “poor functional prognosis group” (mRS4-6) (P <0.05) No statistical significance (P> 0.05). CONCLUSIONS: CSF tau, S100B concentrations in PCIS patients are associated with stroke characteristics, whereas NSE CSF concentrations are independent of stroke characteristics.