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目的探讨醒脑静注射液治疗癫痫持续状态的临床疗效及安全性。方法将66例癫痫持续状态患者随机分为对照组和观察组,各33例。两组患者均给予地西泮、苯巴比妥治疗,对照组在此基础上加用醒脑静静脉滴注,比较两组的临床疗效和不良反应情况。结果对照组和观察组总有效率分别为90.9%和72.7%,差异有统计学意义(P<0.05)。两组不良反应均较轻微,停药后均自行消失,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论地西泮、苯巴比妥与醒脑静联合治疗癫痫持续状态,临床疗效显著,副作用少,该用药方案安全有效,值得临床推广应用。
Objective To investigate the clinical effect and safety of Xingnaojing injection in the treatment of status epilepticus. Methods Sixty-six patients with status epilepticus were randomly divided into control group and observation group, with 33 cases in each group. Both groups were given diazepam, phenobarbital treatment, the control group on this basis plus Xingnao intravenous infusion, the two groups were compared the clinical efficacy and adverse reactions. Results The total effective rate of control group and observation group were 90.9% and 72.7%, respectively, with significant difference (P <0.05). Adverse reactions were mild in both groups, disappearing on their own after discontinuation of the two groups, the incidence of adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Diazepam, phenobarbital and Xingnaojing combined treatment of status epilepticus, clinical curative effect is obvious, fewer side effects, the drug regimen safe and effective, worthy of clinical application.