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目的评价畲药麻锦煎及美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法将溃疡性结肠炎患者60例采用分层随机化方法分为畬药组与西药组每组30例。畲药组采用麻锦煎口服及麻锦灌肠方保留灌肠;西药组予口服美沙拉嗪肠溶片。观察2组患者溃疡性结肠炎疾病活动指数评分(UC-DAI)及中医临床证候疗效。结果治疗后2组的DAI评分较治疗前均明显下降(P<0.05);畲药组轻度患者治疗后DAI评分低于西药组,差异均有统计学意义(P<0.05);治疗后2组中度患者DAI评分无显著差异(P>0.05)。畲药组中医证候疗效总有效率为83.3%,西药组中医证候疗效总有效率为80.0%,差异无统计学意义(χ2=0.605,P>0.05)。结论畲药麻锦煎口服及灌肠及美沙拉嗪肠溶片口服对轻、中度活动期溃疡性结肠炎湿热内蕴证的患者均有良好疗效,对轻度溃疡性结肠炎治疗效果更佳。
Objective To evaluate the clinical efficacy of She drug Majian decoction and mesalazine in the treatment of ulcerative colitis. Methods Sixty patients with ulcerative colitis were divided into two groups according to the stratified randomization method: She drug group and western medicine group. She drug group with Ma Jin fried ointment and Ma Jin enema retention enema; Western medicine group oral mesalazine enteric-coated tablets. The ulcerative colitis activity index (UC-DAI) and TCM clinical symptoms were observed in two groups. Results The DAI scores of two groups after treatment were significantly lower than those before treatment (P <0.05). DAI scores of patients in Sheji group after treatment were lower than those of western medicine group (P <0.05) There was no significant difference in the DAI scores between the two groups (P> 0.05). The total effective rate of traditional Chinese medicine syndromes was 83.3% in SH group and 80.0% in western medicine group (χ2 = 0.605, P> 0.05). CONCLUSIONS She drug Majimeng orally and enema and mesalazine enteric-coated tablets have good curative effect on patients with mild to moderate active ulcerative colitis damp-heat syndrome and have better therapeutic effect on mild ulcerative colitis .