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本文介绍百日咳杆菌致病作用的细菌组分,如百日咳毒素(PT)、腺苷酸环化酶(AC)毒素、“69KDa”蛋白和菌毛凝集原等,及其与开发新苗苗的关系。还介绍了无细胞菌苗的临床试用和有关合成多肽菌苗、AroA缺失突变株和含69KDa蛋白的无细胞菌苗的研究,以及T细胞介导免疫在百日咳中的重要性。
This article describes the bacterial components of the pathogenic role of Bordetella pertussis such as pertussis toxin (PT), adenylyl cyclase (AC) toxin, “69KDa ” protein and pili agglutinin, etc., Relationship. Clinical trials of cell-free bacterins and studies on synthetic polypeptide vaccines, AroA deletion mutants and cell-free bacterins containing a 69 kDa protein are also described as well as the importance of T cell-mediated immunity in whooping cough.