众所周知,青蒿素及其衍生物是一类作用迅速的抗疟药。青蒿素类的第二代衍生物,即第二代内过氧桥化合物(又统称为Malperox),其前景令人瞩目。目前正在进行寻找更稳定的青蒿素类衍生物及生产全部人工合成的三噁烷类(trioxanes)和四噁烷类 It is well-known that artemisinin and its derivatives are rapidly acting antimalarials. The prospects for the second generation of artemisinin derivatives, the second generation of endoperoxo bridge compounds (also collectively known as Malperox), are remarkable. At present, the search for more stable artemisinin derivatives and the production of all synthetic trioxanes and tetraoxanes