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目的 探讨血沉 (ESR)、C反应蛋白 (CRP)、血乳酸在肺炎引起的全身炎症反应综合征 /多器官功能不全综合征(SIRS/MODS)发病过程中的意义。 方法 61例肺炎患儿根据小儿SIRS诊断标准分为SIRS组 (n =42 )和非SIRS组 (n =19) ,SIRS组根据其符合SIRS诊断标准 2条、3条分为S1 组 (n =3 4 )、S2 组 (n =8) ,于入院第 1天分别测定血沉、C反应蛋白、血乳酸。结果 SIRS组与非SIRS组ESR、CRP、血乳酸无显著差异 (P >0 0 5 ) ,S2 组比非SIRS组ESR、CRP明显升高 (P <0 0 5 ) ;发生 4个器官功能不全组比非MODS组ESR、CRP、血乳酸明显升高 (P <0 0 5 )。 结论 ESR、CRP、血乳酸可作为重度SIRS/MODS的辅助指标 ,肺炎患儿符合 2条标准即诊断SIRS的临床意义值得商榷。
Objective To investigate the significance of ESR, CRP and BLA in the pathogenesis of systemic inflammatory response syndrome / multiple organ dysfunction syndrome (SIRS / MODS) caused by pneumonia. Methods Sixty-one children with pneumonia were divided into SIRS group (n = 42) and non-SIRS group (n = 19) according to SIRS diagnostic criteria. Two patients with SIRS were divided into two groups according to SIRS diagnostic criteria and three were divided into S1 group (n = In group S2 (n = 8), ESR, C-reactive protein and blood lactate were measured on the first day after admission. Results There were no significant differences in ESR, CRP and blood lactate between SIRS group and non-SIRS group (P> 0.05), but the ESR and CRP in S2 group were significantly higher than those in non-SIRS group (P <0.05) Compared with non-MODS group, ESR, CRP and blood lactate were significantly increased (P <0.05). Conclusions ESR, CRP and blood lactate may serve as auxiliary indicators for severe SIRS / MODS. The clinical significance of meeting the two criteria for diagnosis of SIRS in children with pneumonia is debatable.