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目的研究早产儿甲状腺功能。方法将青岛大学医学院附属医院2004年10月至2005年10月收治的早产儿60例按胎龄分成两组小胎龄早产儿组(A组,胎龄<34周,n1=30),大胎龄早产儿组(B组,胎龄≥34周,n2=30)。对照组为我院出生的正常足月儿30例,应用放免法对3组新生儿生后第1,7天血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平进行测定。结果A、B组及对照组血清FT3、FT4生后1～7d呈下降趋势;对照组生后第1,7天血清FT3、FT4明显高于A、B组,B组明显高于A组;血清TSH在A、B及对照组生后呈下降过程;生后第1天对照组TSH>A组>B组;生后第7天,血清TSHA组高于B组和对照组,而B组与对照组差异无显著性。结论早产儿生后甲状腺功能有暂时性低下,胎龄越小,功能越低,生后应激反应持续时间越长。
Objective To study thyroid function in premature infants. Methods 60 cases of preterm infants admitted from October 2004 to October 2005 in Affiliated Hospital of Qingdao University Medical College were divided into two groups according to gestational age (group A, gestational age <34 weeks, n1 = 30) Large gestational age premature children group (B group, gestational age ≥34 weeks, n2 = 30). Control group was born in our hospital, 30 cases of normal full-term children, the application of radioimmunotherapy on the first three days after birth, neonatal triosalicyclic triiodothyronine (FT3), free thyroxine (FT4), promote Thyroid hormone (TSH) levels were measured. Results The serum levels of FT3 and FT4 in groups A, B and control decreased from 1st to 7th day after birth. FT3 and FT4 in serum of control group on day 1,7 were significantly higher than those in groups A and B, and were significantly higher in group B than in group A; Serum TSH decreased after birth in the A, B and control groups; on the first day after birth, the TSH> A group> B group; on the 7th day after birth, the serum TSHA group was higher than the B group and the control group, while the B group No significant difference with the control group. Conclusions The thyroid function of premature infants has transient hypothyroidism. The smaller the gestational age, the lower the function, the longer the duration of postnatal stress response.