论文部分内容阅读
目的探讨阿托伐他汀对冠心病患者血脂及血管内皮功能的影响。方法选自2006年1月—2009年5月南阳市油田总医院门诊或住院冠心病并血脂异常患者186例。选用不同剂量阿托伐他汀进行治疗,观察疗效及治疗前和治疗后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肱动脉流量介导性舒张(Flow-mediated dilation,FMD)功能检测。结果所有病例均顺利完成全部疗程的治疗,无中途停药和不配合治疗,其中A组总有效率85.5%,B组总有效率95.83%。结论阿托伐他汀为强效的调脂新药,临床疗效确切,安全可靠。除有较强的调脂作用外,还具有强大的改善血管内皮功能的作用。
Objective To investigate the effect of atorvastatin on blood lipid and endothelial function in patients with coronary heart disease. Methods From January 2006 -2009 May Nanyang Oilfield General Hospital outpatient or hospitalized patients with coronary heart disease and dyslipidemia in 186 cases. Atorvastatin in different doses was used for treatment. The therapeutic effect and the changes of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL- C), flow-mediated dilation (FMD) function test of brachial artery. Results All cases were successfully completed the whole course of treatment, without stopping and without treatment, of which A group of total effective rate was 85.5%, B group total efficiency of 95.83%. Conclusions Atorvastatin is a potent lipid-lowering drug with definite clinical efficacy and safety. In addition to a strong lipid-lowering effect, but also has a strong role in improving vascular endothelial function.