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目的:探讨不同严重度分级的慢性阻塞性肺疾病急性加重期(AECOPD)患者血浆v WF水平及意义。方法:对24例对照组、21例I、Ⅱ级AECOPD、21例Ⅲ级AECOPD、44例Ⅳ级AECOPD血浆v WF水平进行检测。结果:各级AECOPD患者血浆v WF水平显著高于对照组(P<0.05),不同严重度分级的AECOPD患者血浆v WF水平均存在显著差异(P<0.05)。结论:血浆v WF水平增高提示血管内皮细胞损伤及功能失调,AECOPD患者存在血管内皮细胞损伤及功能失调,对治疗及预后存在不利影响。
Objective: To investigate the significance of vWF levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with different severity grades. Methods: The plasma levels of vWF were detected in 24 cases of control group, 21 cases of grade A, Ⅱ AECOPD, 21 cases of grade Ⅲ AECOPD and 44 cases of grade Ⅳ AECOPD. Results: The plasma levels of vWF in AECOPD patients at all levels were significantly higher than those in control group (P <0.05). There was significant difference in vWF levels between AECOPD patients with different severity grades (P <0.05). CONCLUSION: Increased plasma vWF levels suggest vascular endothelial cell injury and dysfunction. AECOPD patients have vascular endothelial cell injury and dysfunction, which have adverse effects on the treatment and prognosis.