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目的:制备阿昔洛韦明胶微球,并考察其体外释放性能。方法:采用乳化交联法制备阿昔洛韦明胶微球,通过考察其粒径、包封率、载药量优化处方工艺。结果:该工艺制备的微球光滑圆整,其平均粒径为21μm,粒径分布均匀。载药量、包封率分别为15.3%、80.5%。12min体外累积释药量达95.2%。结论:采用乳化交联法制备的明胶微球具有很好的缓释效果。
Objective: To prepare acyclovir gelatin microspheres and study its in vitro release performance. Methods: Aciclovir gelatin microspheres were prepared by emulsion cross-linking method. The particle size, encapsulation efficiency and drug loading were optimized. Results: The prepared microspheres were smooth and round, the average particle size was 21μm, the particle size distribution was uniform. Drug loading, encapsulation efficiency were 15.3%, 80.5%. 12min in vitro cumulative release of 95.2%. Conclusion: The gelatin microspheres prepared by emulsion cross-linking have a good sustained-release effect.