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根据以往对胸膜渗出液的免疫学研究,发现恶性胸液中IgG 低于非恶性胸液,结核性胸液中补体消耗增加;但此发现对常规诊断无特异性。抗可溶性终末补体复合物的单克隆抗体(SC5b-9)试用于区别结核、恶性和其他胸膜渗出液。SC5b-9可能是在补体激活中C5b-7期新生的C5b-9与S 蛋白粘接而产生。SC5b-9在结核引起的胸膜渗出液中的浓度显著高于血浆,提示胸膜腔补体激活。所有26例结核性渗出液患者胸水SC5b-9浓度均超过2.0mg/L;而20例恶性渗出的患者胸水SC5b-9浓度低于2.0mg/L。但类风湿、某些类肺炎、和经治疗的恶性渗出液SC5b-9
According to previous immunological studies of pleural effusion, IgG in malignant pleural effusion was found to be lower than that of non-malignant pleural effusion, and complement depletion in tuberculous pleural effusion was found; however, this finding was not specific for routine diagnosis. Monoclonal antibodies against soluble final complement complex (SC5b-9) were used to distinguish tuberculosis, malignancy and other pleural exudates. SC5b-9 may be caused by C5b-9 C5b-9 binding to S protein during complement activation. The concentration of SC5b-9 in pleural effusions caused by tuberculosis was significantly higher than that of plasma, suggesting that pleural cavity complement activation. The concentration of SC5b-9 in pleural fluid exceeded 2.0mg / L in all 26 patients with tuberculous exudate, while the concentration of SC5b-9 in pleural effusion was lower than 2.0mg / L in 20 patients with malignant effusion. But rheumatoid, certain types of pneumonia, and treated malignant exudate SC5b-9