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目的:探讨清热、活血、扶正经验方“五黄汤”在组织、细胞水平对静脉炎的干预,为临床推广提供依据。方法:选用4月龄大耳新西兰雄性白兔50只,通过静脉注射0.9%氯化钠注射液并保留静脉留置针120～168h,造成兔双耳外耳缘静脉不同程度的静脉炎。每只兔双耳随机分为观察组和对照组,分别用“五黄汤”和33%硫酸镁湿敷,每天换药2次,5天后取活体标本2cm×1cm,光学显微镜下观察血管病理学变化。结果:在Ⅰ级和Ⅱ级静脉炎治疗中:两组疗效相当,差异无显著意义(P>0.05),而在Ⅲ级静脉炎治疗中观察组疗效明显优于对照组,差异有显著意义(P<0.05)。在对血管血栓栓塞和炎症细胞浸润的改善方面,观察组明显优于对照组(P<0.05)。结论:“五黄汤”是临床治疗静脉炎的有效验方,疗效优于硫酸镁,是值得推广的中药方剂。
OBJECTIVE: To investigate the effects of heat-clearing, blood-activating, and strengthening the “wuhuangtang” on phlebitis at the tissue and cellular levels to provide evidence for clinical promotion. METHODS: Fifty male New Zealand white rabbits aged 4 months were selected and intravenously injected with 0.9% sodium chloride solution and retained intravenous indwelling needles for 120-168 hours, resulting in different degrees of phlebitis in the external ear veins of rabbit ears. Each rabbit’s ears were randomly divided into the observation group and the control group. Wet dressings were made with “Wonghuang Decoction” and 33% magnesium sulfate respectively. The dressing was changed twice a day. After 5 days, the living specimens were taken 2cm x 1cm. The blood vessels were observed under an optical microscope. Pathological changes. RESULTS: In the treatment of grade I and II phlebitis: the efficacy of the two groups was comparable and the difference was not significant (P>0.05). In the treatment of grade III phlebitis, the efficacy of the observation group was significantly better than that of the control group. The difference was significant ( P<0.05). In the improvement of vascular thromboembolism and inflammatory cell infiltration, the observation group was significantly better than the control group (P<0.05). Conclusion: “Wuhuang Decoction” is an effective prescription for clinical treatment of phlebitis and its efficacy is better than that of magnesium sulfate. It is a traditional Chinese medicine prescription worthy of promotion.