绝经后妇女使用雌激素替代治疗(ERT)可缓解绝经期症状,防止骨质疏松。但应注意减少肝代谢改变及由此引起的高血压、高血脂症、动静脉血栓栓塞性疾病及心血管疾患等并发症。对给药途径或雌激素剂型、剂量对防止并发症何者更为重要,各家意见不一。本文通过口服及经皮肤给17β-雌二醇(E_2)前后观察肝及血液各项生物及生化指标的变化,探讨ERT不同给药途径的利弊。受试者分两组:(1)口服组口服粉末化E_2(E_2 Postmenopausal women using estrogen replacement therapy (ERT) can ease menopausal symptoms and prevent osteoporosis. However, care should be taken to reduce liver metabolic changes and the resulting complications of hypertension, hyperlipidemia, arterial and venous thromboembolic diseases and cardiovascular diseases. On the route of administration or estrogen dosage forms, the dose is more important to prevent complications, different opinions. In this paper, the changes of biochemical and biochemical indexes of liver and blood were observed before and after administration of 17β-estradiol (E_2) orally and percutaneously to explore the pros and cons of different routes of administration of ERT. Subjects were divided into two groups: (1) Oral oral powder powdered E_2 (E_2