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目的观察抗甲状腺药物对131I治疗甲亢疗效的影响。方法选取医院收治的甲亢患者90例作为研究对象,均采用131I治疗。病例分组依据:抗甲状腺药物应用情况。90例患者分为A组、B组和C组,每组30例。A组联合应用抗甲状腺药物,B组131I治疗过程中停用抗甲状腺药物,C组单纯131I治疗。观察3组治疗总有效率及患者甲状腺激素FT3、FT4水平的差异。结果与A组、B组比较,C组总有效率更高(P<0.01);B组总有效率稍高于A组,但差异无统计学意义(P>0.05)。C组甲状腺激素FT3、FT4水平较A组和B组更佳(P<0.05);而B组稍好于A组,但差异无统计学意义(P>0.05)。结论抗甲状腺药物对131I治疗甲亢的疗效有明显影响,导致疗效降低,甲状腺功能下降,在治疗时应注意用药方案的选择。
Objective To observe the effect of antithyroid drugs on the therapeutic effect of 131I on hyperthyroidism. Methods Totally 90 hyperthyroid patients admitted to hospital were selected as study subjects, all of whom were treated with 131I. Case group basis: Antithyroid drug application. 90 patients were divided into A group, B group and C group, 30 cases in each group. Antithyroid drugs were administered in combination with Group A, anti-thyroid drugs were discontinued in Group B during 131I treatment, and 131I alone in Group C. The total effective rate of three groups and thyroid hormones FT3, FT4 levels were observed. Results The total effective rate in group C was higher than that in group A and group B (P <0.01). The total effective rate in group B was slightly higher than that in group A, but the difference was not statistically significant (P> 0.05). The levels of thyroid hormones FT3 and FT4 in group C were better than those in group A and B (P <0.05), while those in group B were slightly better than those in group A (P <0.05). Conclusion Antithyroid drugs have a significant effect on the therapeutic effect of 131I on hyperthyroidism, leading to the decrease of therapeutic effect and the decline of thyroid function. At the time of treatment, the choice of medication regimen should be noticed.