论文部分内容阅读
目的观察p VHL在卵巢不同类型上皮性癌中的表达,探讨p VHL在卵巢透明细胞癌诊断价值。方法采用免疫组化En Vision法检测卵巢恶性上皮性癌p VHL的表达。结果 20例卵巢透明细胞癌均弥漫强(+),阳性率为90%;20例卵巢高级别浆液性癌中3例p VHL呈胞质/胞膜(+),阳性率15%;14例卵巢高-中分化宫内膜样腺癌有2例(+),阳性率14.3%,p VHL在浆液性癌和子宫内膜样腺癌中的阳性率明显低于透明细胞癌(p<0.01)。p VHL对卵巢透明细胞癌的敏感性90%,特异性85.2%。结论 p VHL是一种敏感性高的卵巢透明细胞癌标记物,p VHL弥漫强(+)有助于辅助诊断卵巢透明细胞癌,具有潜在的临床价值。
Objective To observe the expression of p VHL in different types of epithelial ovarian cancer and to explore the value of p VHL in the diagnosis of ovarian clear cell carcinoma. Methods Immunohistochemical En Vision method was used to detect the expression of p VHL in ovarian malignant epithelial carcinoma. Results 20 cases of ovarian clear cell carcinoma were diffusely strong (+), the positive rate was 90%. In 20 cases of ovarian high grade serous carcinoma, 3 cases of p VHL were cytoplasm / membrane (+), the positive rate was 15%; 14 cases The positive rate of p VHL in serous carcinoma and endometrioid adenocarcinoma was significantly lower than that in clear cell carcinoma (p <0.01) ). p VHL on ovarian clear cell carcinoma sensitivity 90%, specificity 85.2%. Conclusion p VHL is a highly sensitive marker of ovarian clear cell carcinoma. The diffuse (p VHL) p VHL is helpful to diagnose clear cell carcinoma of the ovary and has potential clinical value.