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目的探讨家栖鼠对抗凝血杀鼠剂的抗药性变化。方法按全国鼠类抗药性监测协作组统一方法,进行无选择性摄毒试验。结果经对惠州市辖区内所捕捉的98只褐家鼠、57只黄胸鼠、11只小家鼠进行抗药性监测,其抗性率分别为1.02%、10.53%、45.45%,其总平均摄药剂量分别为10.1m g/kg、112.57m g/kg、664.35m g/kg,按家栖鼠抗药性检验标准,明显地小家鼠对第一代抗凝血剂杀鼠灵已形成抗药性种群,而黄胸鼠和褐家鼠有产生抗药性个体。结论以小家鼠为优势种的场所,要考虑使用第二代抗凝血灭鼠剂;而以黄胸鼠和褐家鼠为主的场所,则可继续使用第一代抗凝血灭鼠剂,同时应加强对灭鼠药物的敏感性监测,科学、合理用药。
Objective To investigate the changes of drug resistance of domestic rats on anticoagulant rodenticides. Methods According to the unified method of the National Collaborating Group on Resistance Investigation of Rodents, a non-selective toxicity test was conducted. Results The drug resistance of 98 Rattus norvegicus, 57 Rattus flavipectus and 11 Rattus norvegicus captured in the area of Huizhou were tested. The resistance rates were 1.02%, 10.53% and 45.45% The doses of the drugs were 10.1mg / kg, 112.57mg / kg and 664.35mg / kg, respectively. It was obvious that Mus musculus had a resistant population to the first-generation anti-coagulant warfarin , While Rattus flavipectus and Rattus norvegicus develop resistant individuals. Conclusion The dominant species of Mus musculus are the second generation of anticoagulant rodenticides, while the first generation of anticoagulant rodenticides At the same time, we should strengthen the sensitivity of rodent control drug monitoring, scientific and rational drug use.