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目的探讨儿童再生障碍性贫血转化为急性淋巴细胞白血病的特点及其可能原因。方法对儿童再生障碍性贫血转化为急性淋巴细胞白血病的临床资料、细胞形态学、骨髓活检病理、流式细胞仪免疫分型结果进行分析,并结合文献进行复习。结果 19例儿童首发全血细胞减少,诊断为再生障碍性贫血;经过1~4周自然缓解或治疗后缓解;但间隔1~10个月发展为急性淋巴细胞白血病。结论儿童再生障碍性贫血是急性淋巴细胞白血病前期表现;再生障碍性贫血转化为急性淋巴细胞白血病的临床资料及在疾病发展中多种技术联合诊断,有助于提高急性淋巴细胞白血病前期的诊断。
Objective To investigate the characteristics and possible causes of childhood aplastic anemia into acute lymphoblastic leukemia. Methods The clinical data of children with aplastic anemia into acute lymphoblastic leukemia, cell morphology, bone marrow biopsy pathology, immunofluorescence typing results were analyzed and combined with literature review. Results 19 cases of children with first pancytopenia, diagnosis of aplastic anemia; after 1 to 4 weeks of natural remission or treatment to ease; but an interval of 1 to 10 months to develop acute lymphoblastic leukemia. Conclusions Childhood aplastic anemia is the manifestation of acute lymphoblastic leukemia. The clinical data of patients with acute aplastic anemia and acute lymphoblastic leukemia and the combination of multiple techniques in the development of the disease are helpful to improve the diagnosis of acute lymphoblastic leukemia.