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目的探讨联合检测抗环瓜氨酸肽(CCP)抗体和类风湿因子(RF)在类风湿关节炎(RA)诊断中的价值。方法抗-ccp采用化学发光(MEIA)法,RF采用散射速率比浊法检测,取70例RA、130例非RA患者血清检测抗-CCP和RF。结果 70例RA患者中抗-CCP阳性54例,RF阳性52例,两项同时阳性64例,同时阴性6例,故抗-CCP、RF及两者联合检测在RA患者中的阳性率分别为77.1%、74.3%和91.4%;130例非RA患者中抗-CCP阳性5例,RF阳性38例,无1例两项同时阳性,故抗-CCP、RF及抗-CCP和RF联合检测在非RA患者中的阳性率分别为3.85%、29.23%和0。经过统计学分析联合检测与单项检测比较,差异有统计学意义(P<0.01),且RA患者抗-CCP与RF阳性率显著高于非RA患者,差异有统计学意义(P<0.01)。结论抗-CCP和RF联合检测可明显提高RA的诊断率。
Objective To investigate the value of combined detection of anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) in the diagnosis of rheumatoid arthritis (RA). Methods Chemiluminescence (MEIA) method was used for anti-CCp, and turbidimetric method was used for the determination of RF by scattering rate. Seventy patients with RA and 130 non-RA sera were tested for anti-CCP and RF. Results Among the 70 patients with RA, 54 were positive for anti-CPP, 52 were RF positive, 64 were both positive and 6 were negative at the same time. Therefore, the positive rates of anti-CCP, RF and their combined detection in RA were 77.1%, 74.3% and 91.4% respectively. Among 130 non-RA patients, 5 were anti-CCP positive and 38 were RF positive. None of them were positive at the same time. Therefore, anti-CCP, RF, anti- The positive rates in non-RA patients were 3.85%, 29.23%, and 0 respectively. After statistical analysis, there was a significant difference between combined test and single test (P <0.01). The positive rate of anti-CCP and RF in RA patients was significantly higher than that in non-RA patients (P <0.01). Conclusion Combined detection of anti-CCP and RF can significantly improve the diagnostic rate of RA.