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目的:探讨古代中药丸剂赋形剂的使用和意义。方法:对几个古代方剂的处方组成、制法和用法,以及对目前仍在使用的蜜、糊、水性液体3种辅料在古代丸剂中的使用进行讨论分析。结果:古代丸剂中使用的辅料大部分既是药物成分,又是辅料,同时可影响制剂的成型和生物有效性。结论:中药丸剂是一种古老的、至今仍具有较强生命力的剂型。在积极采取新技术开发的同时,应注意吸收传统制剂工艺诸如选药、炮制、煎煮等环节的精华,力求使丸剂的使用符合中医药理论和贴近临床需要。
Objective: To explore the use and significance of ancient Chinese medicine pill excipients. Methods: The prescription composition, preparation method and usage of several ancient prescriptions and the use of three kinds of excipients such as honey, paste and aqueous liquid still in use in ancient pills were discussed and analyzed. Results: Most of the excipients used in ancient pills are both drug components and excipients, and can affect the shaping and bioavailability of the preparation. Conclusion: Chinese medicine pill is an ancient, still has a strong vitality of the dosage form. While actively adopting the development of new technologies, attention should be paid to absorb the essence of traditional preparation processes such as drug selection, processing and decocting so as to make the use of pills comply with the theory of traditional Chinese medicine and close to the clinical needs.