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硫芥是一种糜烂性毒剂 ,作用于皮肤产生红斑、水疱、坏死 ,并能引起眼、呼吸道、消化道黏膜的组织损伤 ,吸收到体内后出现程度不同的全身中毒。目前尚无特效抗毒剂。研究认为其作用机制可能为 :DNA烃化和糖酵解的抑制、蛋白硫醇_Ca2 + 稳态失调、谷胱甘肽 (GSH)的消耗、活性氧 (reactiveoxygensubstances,ROS)的产生等。细胞凋亡也是近年来其毒理作用机制研究的热点。本文综述了近年来该领域的研究进展 ,以期为我们寻找、制定有效的预防和治疗措施提供一些重要的启示。
Sulfur mustard is an erosive agent that acts on the skin to produce erythema, blisters and necrosis, and can cause tissue damage to the eyes, respiratory tract and digestive tract mucosa. After being absorbed into the body, the sulfur poisoning occurs to a different degree. There is no effective anti-virus. Studies suggest that the mechanism may be: DNA alkylation and glycolysis inhibition, protein thiol _Ca2 homeostasis, glutathione (GSH) consumption, reactive oxygen species (ROS) generation. Apoptosis is also the focus of its toxicological mechanism in recent years. This article summarizes the research progress in this field in recent years, and provides some important revelations for us to find and formulate effective preventive and curative measures.