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目的分析及探索对幽门螺杆菌(Hp)阳性的十二指肠球部溃疡患者采用兰索拉唑、左氧氟沙星及克拉霉素等三联方案进行治疗临床疗效。方法收集本科室2014年5月至2016年5月间治疗的十二指肠球部溃疡并幽门螺杆菌阳性的160例患者,根据随机双色球分组法将其随机分成两组:参考组包含80例患者,给予兰索拉唑、阿莫西林及克拉霉素联合方案治疗;治疗组包含80例患者,给予兰索拉唑、左氧氟沙星及克拉霉素联合方案治疗。观察及比较两组患者的临床治疗效果。结果与参考组相比,治疗组患者治疗后的Hp根除率明显较高(P<0.05)。两组治疗的总有效率与不良反应发生率比较(P>0.05)。结论对Hp阳性十二指肠球部溃疡患者采用兰索拉唑、左氧氟沙星及克拉霉素等三联方案进行治疗疗效显著,安全性较高,且可有效提高患者的Hp根除率,值得推广。
Objective To analyze and explore the clinical efficacy of lansoprazole, levofloxacin and clarithromycin in patients with Helicobacter pylori (Hp) -positive duodenal ulcer. Methods A total of 160 patients with duodenal ulcer and Helicobacter pylori who were treated in our department from May 2014 to May 2016 were randomly divided into two groups according to the random two-color ball grouping method: the reference group included 80 cases Patients were treated with lansoprazole, amoxicillin and clarithromycin. The treatment group consisted of 80 patients treated with lansoprazole, levofloxacin and clarithromycin. The clinical effects of two groups were observed and compared. Results Compared with the reference group, the Hp eradication rate after treatment in the treatment group was significantly higher (P <0.05). The total effective rate of treatment and adverse reaction rate (P> 0.05). Conclusions The triple therapy regimen of lansoprazole, levofloxacin and clarithromycin in patients with Hp positive duodenal ulcer has significant curative effect, high safety and can effectively improve the Hp eradication rate of patients, which is worth promoting.