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目的研究恶性肿瘤患者的血栓弹力图临床检测价值。方法应用血栓弹力图仪进行R值、K值、Ma值与Mε值检测;应用凝固法进行APTT、TT、PT检测;应用双缩脲法进行Fg检测。结果恶性肿瘤组血栓弹力图的R值与K值明显缩短、Mε与Ma值明显增宽,与正常对照组比较差异具有统计学意义(P<0.001);恶性肿瘤组APTT、TT、PT、Fg值与正常对照组比较差异无统计学意义(P>0.05)。结论应用血栓弹力图动态观察恶性肿瘤患者凝血状态比传统的凝血相关指标敏感,对指导部分恶性肿瘤治疗具有一定的临床意义。
Objective To study the clinical value of thrombus elastography in patients with malignant tumors. Methods The value of R, K, Ma and Mε were detected by thromboelastography instrument. APTT, TT and PT were detected by coagulation method. Fb was detected by biuret method. Results The values of R and K in thromboelastogram of malignant tumor group were significantly shortened, and the values of Mε and Ma were obviously broadened, which were significantly different from those in normal control group (P <0.001). The expressions of APTT, TT, PT, Fg There was no significant difference between the normal control group and the normal control group (P> 0.05). Conclusions The dynamic observation of coagulation state in patients with malignant tumor using thromboelastography is more sensitive than the traditional coagulation-related indicators, which is of clinical significance for guiding the treatment of some malignant tumors.