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对２０位肾移植术后病人的４１份环孢素（ｃｙｃｌｏｓｐｏｒｉｎ）血样，用美国Ａｂｂｏｔｔ公司的荧光偏振免疫分析法即单克隆全血环孢素测定法（ＳＴＤｘ）和全血环孢素及其代谢物测定法（ＮＳＴＤｘ）进行测定，所得资料用统计学ｔ检验和线性回归分析进行处理。结果显示：服药后８ｈ和１２ｈ体内环孢素原型率有非常显著差异（Ｐ＜０．００１），它们分别为４６％（８ｈ）和３０％（１２ｈ）。在两方法测定结果之间有较好相关性（ｒ＝０．９９，１２ｈ和ｒ＝０．９７，８ｈ）。我们认为，特异性单克隆全血环孢素法能较好地确定体内原型药物浓度，有利于揭示环孢素本身的作用；而非特异性的全血环孢素法能够反映原型药物和主要代谢物的综合作用，由于它们之间存在较好的相关性，可经通过某些换算，来估价和比较它们的治疗浓度范围。
A total of 41 cyclosporin blood samples from 20 patients after renal transplantation were analyzed by the fluorescence polarization immunoassay of monoclonal antibodies (STDx) and whole blood cyclosporin Metabolite Assay (NSTDx) was measured and the data obtained were processed using a statistical t-test and linear regression analysis. The results showed that there was a significant difference (P <0.001) in the rate of cyclosporine 8 and 12 hours after treatment, which were respectively 46% (8h) and 30% (12h). There was a good correlation between the two methods (r = 0.99, 12h and r = 0.97, 8h). We believe that the specific monoclonal whole blood cyclosporine method can better determine the concentration of the prototype drugs in vivo, is conducive to reveal the role of cyclosporine itself; and non-specific method of whole blood cyclosporine can reflect the prototype drugs and the main metabolism The combined effect of substances, because of their good correlation, allows for the evaluation and comparison of their therapeutic concentration ranges by some conversion.