本文报告36例呈慢性肾功能不全表现的IgA肾病患者临床及病理特征。在这些患者中普遍合并高血压(69.4%);大量蛋白尿(30.5%),溶菌酶尿(86.0%),低渗尿(91.7%),尿酸化异常(87.0%)及慢性潜在性感染灶(44.4%)。病理改变除肾小球硬化外,往往有严重的肾间质小管损害。本文结果表明,IgA肾病的预后除了与高血压、肾小球硬化有关外,与肾间质小管功能关系密切。而体内潜在性感染灶往往是造成疾病急性恶化重要的诱发因素。 This article reports the clinical and pathological features of 36 patients with IgAN with chronic renal failure. High prevalence of hypertension (69.4%), mass proteinuria (30.5%), lysozyme urine (86.0%), hypotonic urine (91.7%), uric acidosis (87.0%) and chronic latent infection (44.4%). Pathological changes in addition to glomerulosclerosis, often have serious renal tubulointerstitial damage. Our results show that, in addition to the prognosis of IgA nephropathy with hypertension, glomerular sclerosis, and renal tubulointerstitial function closely related. The underlying latent infection in the body is often an important predisposing factor for the acute worsening of the disease.