论文部分内容阅读
目的对住院2型糖尿病患者采用更短期胰岛素泵强化治疗观察胰岛功能改善情况,为患者出院后制定合理的治疗方案提供正确的指导。方法对194例2型糖尿病住院患者行10 d左右的胰岛素泵强化治疗,配合严格饮食和运动治疗,住院后要求3 d内血糖达标(空腹血糖<6.0 mmol/L、餐后2 h血糖<8.0 mmol/L),治疗前后分别应用改良Homa公式和空腹C肽评价强化治疗前后胰岛功能的改善情况。采用SPSS 19.0统计软件进行数据分析,治疗前后数据的比较采用配对t检验。结果胰岛素泵治疗期间,低血糖发生率为0.045次/d,低血糖主要发生在夜间凌晨(42%),在强化治疗后,胰岛功能和胰岛素抵抗均有明显改善,差异均有统计学意义(t值分别为5.55、4.30,P<0.01),而治疗前后C肽差异无统计学意义(t=0.29,P=0.775)。结论超短期的胰岛素泵强化治疗能改善住院2型糖尿病患者的胰岛功能,应用改良Homa公式能更全面反映血糖和胰岛素抵抗对胰岛素分泌的影响。
Objective To investigate the improvement of pancreatic islet function in patients with type 2 diabetes mellitus by short-term insulin pump intensive treatment and provide proper guidance for the patients to develop rational treatment plan after discharge. Methods Ninety-four inpatients with type 2 diabetes underwent intensive insulin therapy for about 10 days with strict diet and exercise therapy. Blood glucose levels within 3 days after admission were required (fasting blood glucose <6.0 mmol / L, postprandial blood glucose <8.0 h mmol / L). Before and after treatment, the improved Homa formula and fasting C-peptide were used to evaluate the improvement of islet function before and after intensive treatment. SPSS 19.0 statistical software was used for data analysis, before and after treatment data were compared using paired t test. Results During the insulin pump treatment, the incidence of hypoglycemia was 0.045 times / d. Hypoglycemia occurred mainly in the early evening at night (42%). After intensive treatment, the islet function and insulin resistance were significantly improved, with statistical significance ( t values were 5.55,4.30, P <0.01), while there was no significant difference in C peptide before and after treatment (t = 0.29, P = 0.775). Conclusion Ultrashort insulin pump therapy can improve islet function in hospitalized patients with type 2 diabetes. The improved Homa formula can more fully reflect the effect of blood glucose and insulin resistance on insulin secretion.