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目的探讨血管生成素2(Ang-2)和miR-126与T2DM患者大血管病变的关系。方法检测241例T2DM患者和104名健康对照(NC)者的临床指标、不同时相的胰岛素及C-P水平,测定单核细胞趋化蛋白-1(MCP-1)、血管内皮舒张因子(一氧化氮,NO)、血清miR-126和Ang-2表达水平,分析Ang-2与血管内皮细胞功能、miR-126表达水平的关系。结果 T2DM合并大血管病变(T2DM+CVD)、T2DM未合并大血管病变(T2DM)组Ang-2水平与NC组比较差异有统计学意义(P<0.05)。与T2DM、NC组比较,T2DM+CVD组Ang-2水平升高,miR-126表达水平降低(P<0.05)。Ang-2与MCP-1呈正相关(r=0.456,P<0.01),与miR-126、NO呈负相关(r=-0.517,P<0.01;r=-0.327,P<0.05)。结论 Ang-2和miR-126与糖尿病大血管病变密切相关。miR-126负性调节Ang-2表达。
Objective To investigate the relationship between angiopoietin 2 (Ang-2) and miR-126 and macroangiopathy in patients with T2DM. Methods The clinical data of 241 patients with T2DM and 104 healthy controls (NC) were detected. Insulin and CP levels were measured at different time points. The levels of MCP-1 and Vasodilator Nitrogen and NO), serum miR-126 and Ang-2 levels, and to analyze the relationship between Ang-2 and the function of vascular endothelial cells and the expression of miR-126. Results There was significant difference in Ang-2 level between T2DM with macrovascular disease (T2DM + CVD) and T2DM without macroangiopathy (T2DM) compared with NC group (P <0.05). Compared with T2DM and NC group, the level of Ang-2 and the expression of miR-126 in T2DM + CVD group were significantly decreased (P <0.05). Ang-2 was positively correlated with MCP-1 (r = 0.456, P <0.01), and negatively correlated with miR-126 and NO (r = -0.517, P <0.01; r = -0.327, P <0.05). Conclusion Ang-2 and miR-126 are closely related to diabetic macroangiopathy. miR-126 negatively regulates Ang-2 expression.