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目的:探讨血清脂蛋白(a)[Lp(a)]水平与冠状动脉支架置入术后支架内再狭窄的关系。方法:检测152例行经皮球囊冠状动脉成形术加支架置入术的患者Lp(a)水平并调查其一般临床资料,术后行冠状动脉造影随访。采用Logistic多因素逐步回归分析。结果:Logistic多因素逐步回归分析显示,Lp(a)升高是支架术后支架内再狭窄发生的独立危险因素,P=0.036,其RR为2.648,95%可信区间为1.066～6.575。其他因素如吸烟、糖尿病、支架类型在再狭窄与正常组间也存在明显区别,差异有统计学意义,与支架内再狭窄发生有关。结论:Lp(a)水平升高是发生冠状动脉支架术后再狭窄的独立危险预测因素。
Objective: To investigate the relationship between serum lipoprotein (a) [Lp (a)] and in-stent restenosis after coronary stent implantation. Methods: The levels of Lp (a) in 152 patients undergoing percutaneous balloon coronary angioplasty and stenting were examined and their general clinical data were investigated. Coronary angiography was followed up. Logistic regression analysis was performed by multivariate logistic regression. Results: Logistic regression analysis showed that Lp (a) elevation was an independent risk factor for in-stent restenosis with P = 0.036, RR was 2.648 and 95% confidence interval was 1.066-6.575. Other factors such as smoking, diabetes, stent type in restenosis and normal group there are also significant differences, the difference was statistically significant, and in-stent restenosis related. CONCLUSION: Elevated Lp (a) level is an independent predictor of restenosis after coronary stenting.