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目的分析肿瘤标志物联检在胃癌早期诊断临床应用。方法 30例胃癌患者作为实验组,另抽取同期30例慢性萎缩性胃炎伴随重度不典型增生的患者作为对照组。对这两组患者的血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原724(CA724)、糖类抗原242(CA242)进行检测比较。结果实验组患者的的血清CEA、CA199、CA724、CA242明显高于对照组,两组对比差异具有统计学意义(P<0.05)。结论血清CEA、CA199、CA724、CA242的异常升高,可以作为癌变早期诊断的辅助指标,肿瘤标志物联检可以提升早期胃癌诊断的敏感度。
Objective To analyze the clinical application of joint detection of tumor markers in the early diagnosis of gastric cancer. Methods Thirty patients with gastric cancer were selected as the experimental group. Thirty patients with chronic atrophic gastritis accompanied by severe dysplasia were selected as the control group. The CEA, carbohydrate antigen 199 (CA199), carbohydrate antigen 724 (CA724), carbohydrate antigen 242 (CA242) were compared between the two groups. Results The serum levels of CEA, CA199, CA724 and CA242 in the experimental group were significantly higher than those in the control group, and the difference between the two groups was statistically significant (P <0.05). Conclusions The abnormal increase of serum CEA, CA199, CA724 and CA242 can be used as auxiliary indicators for the early diagnosis of cancer. The detection of tumor markers can improve the sensitivity of early gastric cancer diagnosis.