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目的：探讨急性白血病合并真菌感染的临床特点及影响预后的因素。方法回顾性分析2007年8月~2014年5月我院血液科收治的急性白血病合并真菌感染患者的临床资料，对影响预后的因素采用单因素字2检验及多因素L ogistic回归分析。结果急性白血病患者真菌感染发生率为27.54%，病死率11.46豫；真菌培养阳性者58例次，共检出82株真菌，酵母菌69株(占84.15%)，霉菌9株，(占10.98%)；感染部位以呼吸道(占64.63%)、消化道(占23.13%)、口腔(占8.84%)多见；经Logistic回归分析人选的年龄≥60岁、中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭四因素在治疗有效组和无效组之间有显著性差异(<0.05)。中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭三因素在存活组和死亡组间有显著性差异(<0.05)。结论肺部、消化道、口腔是急性白血病合并真菌感染主要感染部位，白色念珠菌感染占首位，年龄≥60岁、中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭是急性白血病合并真菌感染治疗无效的不良预后因素。其中中性粒细胞缺乏≥2w、有既往真菌感染病史、合并多器官功能衰竭是急性白血病合并真菌感染死亡的危险因素。“,”Objective To investigate the clinical characteristics and prognosis fungal Infection in patients with acute leukemia. Methods The cases of fungal infection in acute leukemia patients ,between 2007 /8 and 2014/05,were col ected retrospectively from hematology department of binzhou people Hospital. The factors which influence the prognostic factors to be investigated .Chi-square test and Logistic regression analysis were used for statistics. Results The incidence of fungal infection in acute leukemia was 27.54%,and mortality rate was 11.46%.The frequently presented fungus was the saccharomyces(84.15%),then mould(10.98%).The common site of infection is the respiratory tract(64.63%)、intestinal tract(23.13%),oral cavity(8.84%),According to multivariate Logistic regression analysis, only age、the duration of neutropenia≥2weeks,history of fungus infection multiple organ failure are the the factors associated with the curative ef ect of fungal infections( <0.05).The duration of neutropenia≥2weeks,history of fungus infection multiple organ failure are the the factors associated with the mortality of fungal infections ( <0.05).Conclusion The common site of fungal infection is the respiratory tract intestinal tract oral cavity;The frequently presented fungus was the saccharomyces,age≥60、the duration of neutropenia ≥2weeks history of fungus infection multiple organ failure are the the factors associated with the curative ef ect of fungal infections.The duration of neutropenia ≥2weeks、history of fungus infection、multiple organ failure are the the factors associated with the mortality of fungal infections.