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目的探讨不同透析方式对慢性肾功能衰竭(CRF)患者免疫功能及生活质量的影响。方法66例CRF患者为研究对象,随机分成血液透析组(A组33例)和血液透析滤过组(B组33例)。比对其血清免疫球蛋白、T淋巴细胞亚群水平变化情况及健康调查简表(SF-36量表)评定结果。结果 1两组患者治疗后血清免疫球蛋白水平及CD8+指标对比差异均无统计学意义(P>0.05);但CD3+、CD4+及CD4+/CD8+等T细胞亚群指标均较治疗前提升,组间对比差异均具有统计学意义(P<0.05);2 B组生活质量评分结果明显优于A组患者,组间对比差异有统计学意义(P<0.05)。结论对CRF患者采用血液透析滤过方案,可有效提升其免疫力,改善免疫功能,提高生活质量,具有临床推广价值。
Objective To investigate the effects of different dialysis methods on immune function and quality of life in patients with chronic renal failure (CRF). Methods 66 CRF patients were randomly divided into hemodialysis group (33 cases) and hemodiafiltration group (33 cases). Compared with the level of serum immunoglobulin, T lymphocyte subsets and health survey profile (SF-36 scale) assessment results. Results 1 There was no significant difference in serum immunoglobulin level and CD8 + index between the two groups (P> 0.05), but the indexes of T cell subsets such as CD3 +, CD4 + and CD4 + / CD8 + (P <0.05). The quality of life score of group B was significantly better than that of group A (P <0.05). The difference between the two groups was statistically significant (P <0.05). Conclusion Hemodialysis filtration in patients with CRF can improve their immunity, improve immune function and improve their quality of life, which is of clinical value.