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目的:探讨鲜车前草糊剂外用对大鼠创伤性溃疡的影响。方法:采用特制致伤器造大鼠创伤性溃疡模型,观察大、小剂量鲜车前草糊剂对创伤性溃疡模型大鼠溃疡面积及溃疡局部组织形态的影响。结果:大鼠创伤性溃疡模型造模成功;与模型组比较,大、小剂量鲜车前草糊剂组在给药的第3、7、10天均可显著缩小鼠创伤性溃疡皮肤面积(P<0.01,P<0.05);大、小剂量鲜车前草糊剂组均可显著改善大鼠创伤性溃疡模型局部组织的病理变化(P<0.01)。结论:鲜车前草糊剂外用对创伤性溃疡大鼠具有好的治疗作用。
Objective: To investigate the effect of fresh plantain paste on traumatic ulcer in rats. Methods: A rat model of traumatic ulcer was made with a special wound-healing device. The effects of large and small doses of fresh plantain paste on ulcer area and local tissue morphology of ulcer in rats with traumatic ulcer were observed. Results: The model of traumatic ulcer in rats was successfully established. Compared with the model group, both the large and small doses of fresh plantain paste group could significantly reduce the skin area of traumatic ulcer rats on the 3rd, 7th and 10th day P <0.01, P <0.05). The pathological changes of the local tissue in traumatic ulcer model of rats were significantly improved by both large and small doses of fresh plantain paste group (P <0.01). Conclusion: The fresh plantain paste topical traumatic ulcer rats have a good therapeutic effect.